Adiponectin up-regulates the decrease of myocardial autophagic flux induced by β₁ -adrenergic receptor autoantibody partly dependent on AMPK.

ABSTRACT: Cardiomyocytes autophagy is essential for maintaining cardiac function. Our previous studies have found that β₁ -adrenergic receptor autoantibody (β₁ -AA) induced the decreased myocardial autophagic flux, which resulted in cardiomyocyte death and cardiac dysfunction. And other studies demonstrated that β₁ -AA induced the decrease of AMPK phosphorylation, the key hub of autophagy pathway, while adiponectin up-regulated autophagic flux mediated by AMPK. However, it is not clear whether adiponectin improves the inhibition of myocardial autophagic flux induced by β₁ -AA by up-regulating the level of AMPK phosphorylation. In this study, it has been confirmed that β₁ -AA induced the decrease of AMPK phosphorylation level in both vivo and vit

SUBMITTER: Sun C 

PROVIDER: S-EPMC8419161 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature