Comprehensive characterization of pathological stage-related genes of papillary thyroid cancer along with survival prediction.

ABSTRACT: It is crucial to understand the differences across papillary thyroid cancer (PTC) stages, so as to provide a basis for individualized treatments. Here, comprehensive function characterization of PTC stage-related genes was performed and a new prognostic signature was developed for advanced patients. Two gene modules were confirmed to be closely associated with PTC stages and further six hub genes were identified that yield excellent diagnostic efficiency between tumour and normal tissues. Genetic alteration analysis indicates that they are much conservative since mutations in the DNA of them rarely occur, but changes of DNA methylation on these six genes show that 12 DNA methylation sites are significantly associated with their corresponding genes' expression. Validation data set testing a

SUBMITTER: Xu L 

PROVIDER: S-EPMC8419169 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature