Peripheral blood transcriptome heterogeneity and prognostic potential in lung cancer revealed by RNA-Seq.

ABSTRACT: Understanding of the complex interaction between the peripheral immune system and lung cancer (LC) remains incomplete, limiting patient benefit. Here, we aimed to characterize the host peripheral immune response to LC and investigate its potential prognostic value. Bulk RNA-sequencing data of peripheral blood leucocytes (PBLs) from healthy volunteers and LC patients (n = 142) were analysed for characterization of host systemic immunity in LC. We observed broad blood transcriptome perturbations in LC patients that were heterogeneous, as two new subtypes were established independent of histology. Functionally, the heterogeneity between the two subtypes included dysregulation of diverse biological processes, such as the cell cycle, blood coagulation and inflammatory signalling pathways, toget

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC8419186 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature