Reduced CCR6⁺IL-17A⁺Treg Cells in Blood and CCR6-Dependent Accumulation of IL-17A⁺Treg Cells in Lungs of Patients With Allergic Asthma.

ABSTRACT: Human regulatory T (Treg) cells play a central role in controlling allergic inflammation in the airways. A reduced number of peripheral Treg cells and decreased suppressive function have been previously reported in the pathogenesis of allergic asthma. However, the characteristic role of specific Treg cell subsets and their mechanisms in the pathogenesis of allergic asthma remain unclear. In this study, we examined the proportion of different Treg cell subsets in both healthy subjects and patients with allergic asthma using flow cytometry and single-cell RNA sequencing. The migration function of the cells was compared using cell sorting and Transwell experiments. Furthermore, two allergen-challenged mouse models and a cell transfer experiment were used to examine the role of these Treg subs

SUBMITTER: Shen X 

PROVIDER: S-EPMC8419235 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature