Effects of Naringin on Cardiomyocytes From a Rodent Model of Type 2 Diabetes.

ABSTRACT: Diabetic cardiomyopathy (DCM) is a primary disease in diabetic patients characterized by diastolic dysfunction leading to heart failure and death. Unfortunately, even tight glycemic control has not been effective in its prevention. We have found aberrant diastolic Ca²⁺ concentrations ([Ca²⁺]_d), decreased glucose transport, elevated production of reactive oxygen species (ROS), and increased calpain activity in cardiomyocytes from a murine model (db/db) of type 2 diabetes (T2D). Cardiomyocytes from these mice demonstrate significant cell injury, increased levels of tumor necrosis factor-alpha and interleukin-6 and expression of the transcription nuclear factor-κB (NF-κB). Furthermore, decreased cell viability, and reduced expression of Kir6.2, SUR1, and SUR2

SUBMITTER: Uryash A 

PROVIDER: S-EPMC8419284 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature