Acute Liver Injury in Patients Hospitalized with COVID-19.

ABSTRACT:

Introduction

The prevalence and significance of acute liver injury in patients with COVID-19 are poorly characterized.

Methods

Patients with confirmed COVID-19 who were hospitalized in geographically diverse medical centers in North America were included. Demographics, symptoms, laboratory data results, and outcomes were recorded. Linear and logistic regression identified factors associated with liver injury, in-hospital mortality, and length of stay (LOS).

Results

Among 1555 patients in the cohort, most (74%) had an elevated alanine aminotransferase (ALT) during hospitalization, which was very severe (> 20 × upper limit of normal [ULN]) in 3%. Severe acute liver injury (ALI) was uncommon, occurring in 0.1% on admission and 2% during hospitalization. No patient develo

SUBMITTER: Sobotka LA 

PROVIDER: S-EPMC8419385 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature