JKAP relates to disease risk, severity, and Th1 and Th17 differentiation in Parkinson's disease.

ABSTRACT:

Objective

JNK pathway-associated phosphatase (JKAP) is previously reported to regulate immune/inflammatory process via T-cell signaling, and closely involves in neurological diseases, while its implication in Parkinson's disease (PD) is unknown. Therefore, this study aimed to investigate the correlation of JKAP with Th1/Th2/Th17 cells and their clinical roles in PD patients, and then further explore the effect of JKAP on regulating CD4⁺ T-cell differentiation in PD.

Methods

Totally 50 PD patients and 50 age-/gender-matched controls were enrolled. Their blood samples were collected and proposed to ELISA and flow cytometry assays for JKAP, Th1, Th2, and Th17 measurements. In vitro, CD4⁺ T cells were isolated from PD patients then transfected with JKAP ove

SUBMITTER: Yang Q 

PROVIDER: S-EPMC8419400 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature