Gut microbiome is associated with multiple sclerosis activity in children.

ABSTRACT:

Objective

To identify features of the gut microbiome associated with multiple sclerosis activity over time.

Methods

We used 16S ribosomal RNA sequencing from stool of 55 recently diagnosed pediatric-onset multiple sclerosis patients. Microbiome features included the abundance of individual microbes and networks identified from weighted genetic correlation network analyses. Prentice-Williams-Peterson Cox proportional hazards models estimated the associations between features and three disease activity outcomes: clinical relapses and both new/enlarging T2 lesions and new gadolinium-enhancing lesions on brain MRI. Analyses were adjusted for age, sex, and disease-modifying therapies.

Results

Participants were followed, on average, 2.1 years. Five microbes were nominally a

SUBMITTER: Horton MK 

PROVIDER: S-EPMC8419410 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature