Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability.

ABSTRACT:

Background

Weight loss through lifestyle modification is recommended for patients with nonalcoholic fatty liver disease (NAFLD). Recent studies have suggested that repeated loss and gain of weight is associated with worse health outcomes. This study aimed to examine the association between weight variability and the risk of NAFLD in patients without diabetes.

Methods

We examined the health-checkup data of 30,708 participants who had undergone serial examinations between 2010 and 2014. Weight variability was assessed using coefficient of variation and the average successive variability of weight (ASVW), which was defined as the sum of absolute weight changes between successive years over the 5-year period divided by 4. The participants were classified according to the baselin

SUBMITTER: Jung I 

PROVIDER: S-EPMC8419611 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature