Foxm1 regulates neural progenitor fate during spinal cord regeneration.

ABSTRACT: Xenopus tadpoles have the ability to regenerate their tails upon amputation. Although some of the molecular and cellular mechanisms that globally regulate tail regeneration have been characterised, tissue-specific response to injury remains poorly understood. Using a combination of bulk and single-cell RNA sequencing on isolated spinal cords before and after amputation, we identify a number of genes specifically expressed in the spinal cord during regeneration. We show that Foxm1, a transcription factor known to promote proliferation, is essential for spinal cord regeneration. Surprisingly, Foxm1 does not control the cell cycle length of neural progenitors but regulates their fate after division. In foxm1^-/- tadpoles, we observe a reduction in the number of neurons in the regene

SUBMITTER: Pelzer D 

PROVIDER: S-EPMC8419688 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature