Endophilin A2 regulates B-cell endocytosis and is required for germinal center and humoral responses.

ABSTRACT: Antigen-specific B-cell responses require endosomal trafficking to regulate antigen uptake and presentation to helper T cells, and to control expression and signaling of immune receptors. However, the molecular composition of B-cell endosomal trafficking pathways and their specific roles in B-cell responses have not been systematically investigated. Here, we report high-throughput identification of genes regulating B-cell receptor (BCR)-mediated antigen internalization using genome-wide functional screens. We show that antigen internalization depends both on constitutive, clathrin-mediated endocytosis and on antigen-induced, clathrin-independent endocytosis mediated by endophilin A2. Although endophilin A2-mediated endocytosis is dispensable for antigen presentation, it is selectively requ

SUBMITTER: Malinova D 

PROVIDER: S-EPMC8419706 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature