Bioluminescent imaging in induced mouse models of endometriosis reveals differences in four model variations.

ABSTRACT: Our understanding of the aetiology and pathophysiology of endometriosis remains limited. Disease modelling in the field is problematic as many versions of induced mouse models of endometriosis exist. We integrated bioluminescent imaging of 'lesions' generated using luciferase-expressing donor mice. We compared longitudinal bioluminescence and histology of lesions, sensory behaviour of mice with induced endometriosis and the impact of the gonadotropin-releasing hormone antagonist Cetrorelix on lesion regression and sensory behaviour. Four models of endometriosis were tested. We found that the nature of the donor uterine material was a key determinant of how chronic the lesions were, as well as their cellular composition. The severity of pain-like behaviour also varied across models. Althoug

SUBMITTER: Dorning A 

PROVIDER: S-EPMC8419713 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature