Clinicopathological and molecular characterizations of pulmonary NUT midline carcinoma.

ABSTRACT:

Introduction

Pulmonary nuclear protein of the testis (NUT) midline carcinoma (NMC) is a aggressive cancer with t (15, 19) translocation. Here we present the clinicopathological characteristics and molecular genetics alterations of primary pulmonary NMC.

Methods

Fluorescence in situ hybridization (FISH) assay was performed to evaluate NUT translocation. Next generation sequencing (NGS) was performed to investigate genomic landscape. A panel of 289 lung cancer tissues with undifferentiation was retrospectively screened for NUT expression by immunohistochemical (IHC) assay.

Results

Overall, 2136 lung cancer samples were reviewed. We consecutively identified 12 cases of primary pulmonary NMC. Computed tomography revealed centrally located bulky lung mass with ipsilateral

SUBMITTER: Xie M 

PROVIDER: S-EPMC8419746 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature