A MUCINs expression signature impacts overall survival in patients with clear cell renal cell carcinoma.

ABSTRACT:

Background

Kidney cancer, especially clear cell renal cell carcinoma (ccRCC), is one of the most common cancers in the urinary system. Previous studies suggested that certain members of MUCINs could serve as independent predictors for the survival of ccRCC patients. None of them, however, is robust enough to predict prognosis accurately.

Objective

To analyze the correlation of MUCINs alterations and their expression levels with the prognosis of ccRCC patients and develop a prognosis-related predictor.

Methods

We applied whole-exome sequencing in samples from 22 Chinese ccRCC patients to identify genetic alterations in MUCIN genes and analyzed their genetic alterations, expression, and correlation with survival using the TCGA, GSE73731, and GSE29069 datasets.

Result

SUBMITTER: Meng H 

PROVIDER: S-EPMC8419780 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature