Multi-parametric MRI phenotype with trustworthy machine learning for differentiating CNS demyelinating diseases.

ABSTRACT:

Background

Misdiagnosis of multiple sclerosis (MS) and neuromyelitis optica (NMO) may delay the treatment, resulting in poor prognosis. However, the precise identification of these two diseases is still challenging in clinical practice. We aimed to evaluate the value of quantitative radiomic features extracted from the brain white matter lesions for differential diagnosis of MS and NMO.

Methods

We recruited 116 CNS demyelinating patients including 78 MS, and 38 NMO. Three neuroradiologists performed visual differential diagnosis based on brain MRI for comparison purpose. A multi-level scheme was designed to harness the selection of discriminative and stable radiomics features extracted from brain while mater lesions in T1-MPRAGE, T2 sequences and clinical factors. Based on t

SUBMITTER: Huang J 

PROVIDER: S-EPMC8419989 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature