Ischemic preconditioning protects the heart against ischemia-reperfusion injury in chronic kidney disease in both males and females.

ABSTRACT:

Background

Uremic cardiomyopathy is a common cardiovascular complication of chronic kidney disease (CKD) characterized by left ventricular hypertrophy (LVH) and fibrosis enhancing the susceptibility of the heart to acute myocardial infarction. In the early stages of CKD, approximately 60% of patients are women. We aimed to investigate the influence of sex on the severity of uremic cardiomyopathy and the infarct size-limiting effect of ischemic preconditioning (IPRE) in experimental CKD.

Methods

CKD was induced by 5/6 nephrectomy in 9-week-old male and female Wistar rats. Two months later, serum and urine laboratory parameters were measured to verify the development of CKD. Transthoracic echocardiography was performed to assess cardiac function and morphology. Cardiomyocyte h

SUBMITTER: Sarkozy M 

PROVIDER: S-EPMC8420010 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature