Second Primary Malignancies in Patients With Hepatocellular Carcinoma: A Population-Based Analysis.

ABSTRACT:

Background

Second primary malignancy (SPM) is becoming a threat for the health of cancer survivors. However, data on the features and results of patients with hepatocellular carcinoma (HCC) with SPMs are scarce. This study aimed to explore the characteristics of HCC patients with SPMs and to screen HCC patients who are at a high risk of developing SPMs.

Method

HCC patients diagnosed between 2000 and 2014 in the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analyzed. Eligible patients were divided into the only one primary malignancy and SPM groups. The Fine-Gray proportional subdistribution hazards model was used to explore the risk factors of developing SPMs, and a competing-risk model was established to predict the probability of developi

SUBMITTER: Kong J 

PROVIDER: S-EPMC8420091 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature