CONVALESCENT plasma for COVID-19: A meta-analysis of clinical trials and real-world evidence.

ABSTRACT:

Background

There is still a lack of consensus on the efficacy of convalescent plasma (CP) treatment in COVID-19 patients. We performed a systematic review and meta-analysis to investigate the efficacy of CP vs standard treatment/non-CP on clinical outcomes in COVID-19 patients.

Methods

Cochrane Library, PubMed, EMBASE and ClinicalTrials.gov were searched from December 2019 to 16 July 2021, for data from clinical trials and observational studies. The primary outcome was all-cause mortality. Risk estimates were pooled using a random-effect model. Risk of bias was assessed by Cochrane Risk of Bias tool for clinical trials and Newcastle-Ottawa Scale for observational studies.

Results

In total, 18 peer-reviewed clinical trials, 3 preprints and 26 observational studies met

SUBMITTER: Kloypan C 

PROVIDER: S-EPMC8420367 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature