Systematic review of host genetic association with Covid-19 prognosis and susceptibility: What have we learned in 2020?

ABSTRACT: Biomarker identification may provide strategic opportunities to understand disease pathophysiology, predict outcomes, improve human health, and reduce healthcare costs. The highly heterogeneous Covid-19 clinical manifestation suggests a complex interaction of several different human, viral and environmental factors. Here, we systematically reviewed genetic association studies evaluating Covid-19 severity or susceptibility to SARS-CoV-2 infection following PRISMA recommendations. Our research comprised papers published until December 31^st , 2020, in PubMed and BioRXiv databases focusing on genetic association studies with Covid-19 prognosis or susceptibility. We found 20 eligible genetic association studies, of which 11 assessed Covid-19 outcome and 14 evaluated infection suscept

SUBMITTER: Ferreira de Araujo JL 

PROVIDER: S-EPMC8420453 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature