Structural insights into the substrate-binding proteins Mce1A and Mce4A from Mycobacterium tuberculosis.

ABSTRACT: Mycobacterium tuberculosis (Mtb), which is responsible for more than a million deaths annually, uses lipids as the source of carbon and energy for its survival in the latent phase of infection. Mtb cannot synthesize all of the lipid molecules required for its growth and pathogenicity. Therefore, it relies on transporters such as the mammalian cell entry (Mce) complexes to import lipids from the host across the cell wall. Despite their importance for the survival and pathogenicity of Mtb, information on the structural properties of these proteins is not yet available. Each of the four Mce complexes in Mtb (Mce1-4) comprises six substrate-binding proteins (SBPs; MceA-F), each of which contains four conserved domains (N-terminal transmembrane, MCE, helical a

SUBMITTER: Asthana P 

PROVIDER: S-EPMC8420772 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature