MAIT Cells Balance the Requirements for Immune Tolerance and Anti-Microbial Defense During Pregnancy.

ABSTRACT: Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset with proinflammatory and cytotoxic effector functions. During pregnancy, modulation of the maternal immune system, both at the fetal-maternal interface and systemically, is crucial for a successful outcome and manifests through controlled enhancement of innate and dampening of adaptive responses. Still, immune defenses need to efficiently protect both the mother and the fetus from infection. So far, it is unknown whether MAIT cells are subjected to immunomodulation during pregnancy, and characterization of decidual MAIT cells as well as their functional responses during pregnancy are mainly lacking. We here characterized the presence and phenotype of Vα7.2⁺CD161⁺ MAIT cells in blood and decid

SUBMITTER: Raffetseder J 

PROVIDER: S-EPMC8420809 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature