Meta-analysis of the association between angiotensin pathway inhibitors and COVID-19 severity and mortality.

ABSTRACT:

Background

Conflicting findings and the analysis of unpublished and retracted data have led to controversy on the safety of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in people with COVID-19 infection. This meta-analysis examined the association of prescription of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) with the outcome from COVID-19.

Methods

A systematic search was conducted to find published studies that reported the outcome of COVID-19 in relation to prescription of ACEI or ARB. Two authors (MF and AD) independently screened and extracted data and assessed study quality and strength of association using standardised tools. The endpoints for the meta-analyses were severe or critical disease out

SUBMITTER: Fernando ME 

PROVIDER: S-EPMC8421238 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature