Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest.

ABSTRACT:

Purpose

The majority of unconscious patients after cardiac arrest (CA) do not fulfill guideline criteria for a likely poor outcome, their prognosis is considered "indeterminate". We compared brain injury markers in blood for prediction of good outcome and for identifying false positive predictions of poor outcome as recommended by guidelines.

Methods

Retrospective analysis of prospectively collected serum samples at 24, 48 and 72 h post arrest within the Target Temperature Management after out-of-hospital cardiac arrest (TTM)-trial. Clinically available markers neuron-specific enolase (NSE) and S100B, and novel markers neurofilament light chain (NFL), total tau, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) were analysed. Normal

SUBMITTER: Moseby-Knappe M 

PROVIDER: S-EPMC8421280 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature