Assessment of myocardial viability with [¹⁵O]water PET: A validation study in experimental myocardial infarction.

ABSTRACT:

Background

Assessment of myocardial viability is often needed in patients with chest pain and reduced ejection fraction. We evaluated the performance of reduced resting MBF, perfusable tissue fraction (PTF), and perfusable tissue index (PTI) in the assessment of myocardial viability in a pig model of myocardial infarction (MI).

Methods and results

Pigs underwent resting [¹⁵O]water PET perfusion study 12 weeks after surgical (n = 16) or 2 weeks after catheter-based (n = 4) occlusion of the proximal left anterior descending coronary artery. MBF, PTF, and PTI were compared with volume fraction of MI in matched segments as assessed by triphenyl tetrazolium chloride staining of LV slices. MBF and PTF were lower in infarcted than non-infarcted segments. Segmental analys

SUBMITTER: Gronman M 

PROVIDER: S-EPMC8421281 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature