PDE11A gene polymorphism in testicular cancer: sperm parameters and hormonal profile.

ABSTRACT:

Purpose

Testicular germ cell tumours (TGCTs) is the most common malignancy among young adult males. The etiology is multifactorial and both environmental and genetic factors play an important role in the origin and development of TGCT. Genetic susceptibility may result from the interaction of multiple common and low-penetrance genetic variants and one of the main candidate genes is PDE11A. Many PDE11A polymorphisms were found responsible for a reduced PDE activity in TGCT patients, who often also display impaired hormone and sperm profile. The aim of this study was to investigate testicular function and PDE11A sequence in testicular cancer cases.

Methods

Semen analysis was performed in 116 patients with unilateral and bilateral sporadic TGCTs and in 120 cancer-free controls.

SUBMITTER: Faja F 

PROVIDER: S-EPMC8421290 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature