MEG source imaging detects optogenetically-induced activity in cortical and subcortical networks.

ABSTRACT: Magnetoencephalography measures neuromagnetic activity with high temporal, and theoretically, high spatial resolution. We developed an experimental platform combining MEG-compatible optogenetic techniques in nonhuman primates for use as a functional brain-mapping platform. Here we show localization of optogenetically evoked signals to known sources in the superficial arcuate sulcus of cortex and in CA3 of hippocampus at a resolution of 750 µm³. We detect activation in subcortical, thalamic, and extended temporal structures, conforming to known anatomical and functional brain networks associated with the respective sites of stimulation. This demonstrates that high-resolution localization of experimentally produced deep sources is possible within an intact brain. This approach is

SUBMITTER: Alberto GE 

PROVIDER: S-EPMC8421372 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature