Ontology highlight
ABSTRACT:
SUBMITTER: Nanaura H
PROVIDER: S-EPMC8421406 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Nanaura Hitoki H Kawamukai Honoka H Fujiwara Ayano A Uehara Takeru T Aiba Yuichiro Y Nakanishi Mari M Shiota Tomo T Hibino Masaki M Wiriyasermkul Pattama P Kikuchi Sotaro S Nagata Riko R Matsubayashi Masaya M Shinkai Yoichi Y Niwa Tatsuya T Mannen Taro T Morikawa Naritaka N Iguchi Naohiko N Kiriyama Takao T Morishima Ken K Inoue Rintaro R Sugiyama Masaaki M Oda Takashi T Kodera Noriyuki N Toma-Fukai Sachiko S Sato Mamoru M Taguchi Hideki H Nagamori Shushi S Shoji Osami O Ishimori Koichiro K Matsumura Hiroyoshi H Sugie Kazuma K Saio Tomohide T Yoshizawa Takuya T Mori Eiichiro E
Nature communications 20210906 1
Nuclear import receptors (NIRs) not only transport RNA-binding proteins (RBPs) but also modify phase transitions of RBPs by recognizing nuclear localization signals (NLSs). Toxic arginine-rich poly-dipeptides from C9orf72 interact with NIRs and cause nucleocytoplasmic transport deficit. However, the molecular basis for the toxicity of arginine-rich poly-dipeptides toward NIRs function as phase modifiers of RBPs remains unidentified. Here we show that arginine-rich poly-dipeptides impede the abil ...[more]