Synthesis of chitosan-grafted poly-acrylic acid (CTS-g-PAA) hydrogel and its potential application in biosensors for signal enhancing and bioanalysis.

ABSTRACT: Nowadays, hydrogels have been attracted a lot of interest due to their immense potential in different fields such as biomedicine and biotechnology. Biodegradable and biocompatible pH-sensitive chitosan-grafted polyacrylic acid (CTS-g-PAA) hydrogel was synthesized by grafting an acrylic acid monomer onto chitosan at the presence of methylene bisacrylamide as a cross-linking agent and ammonium persulphate as an initiator. FT-IR spectroscopy and scanning electron microscopy (SEM) were used to analyze the properties of the obtained hydrogel. The synthesized hydrogel is suitable for the delivery of many hydrophilic drugs or species. Using a multi-walled carbon nanotube modified-glassy carbon electrode (CNT-GCE), the loading and release conditions of Nile Blue (NB) as an electroactive compound w

SUBMITTER: Alipour E 

PROVIDER: S-EPMC8421459 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature