A novel read methodology to evaluate the optimal dose of ⁶⁸Ga-satoreotide trizoxetan as a PET imaging agent in patients with gastroenteropancreatic neuroendocrine tumours: a phase II clinical trial.

ABSTRACT:

Background

⁶⁸Ga-satoreotide trizoxetan is a novel somatostatin receptor antagonist exhibiting higher tumour-to-background ratios and sensitivity compared to ⁶⁸Ga-DOTATOC. This randomised, 2 × 3 factorial, phase II study aimed to confirm the optimal peptide mass and radioactivity ranges for ⁶⁸Ga-satoreotide trizoxetan, using binary visual reading. To that end, 24 patients with metastatic gastroenteropancreatic neuroendocrine tumours received 5-20 µg of ⁶⁸Ga-satoreotide trizoxetan on day 1 of the study and 30-45 µg on day 16-22, with one of three gallium-68  radioactivity ranges (40-80, 100-140, or 160-200 MBq) per visit. Two ⁶⁸Ga-satoreotide trizoxetan PET/CT scans were acquired from each patient post-injection, and were scored

SUBMITTER: Miller CG 

PROVIDER: S-EPMC8421477 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature