Elevated Fibronectin Levels in Profibrotic CD14⁺ Monocytes and CD14⁺ Macrophages in Systemic Sclerosis.

ABSTRACT:

Background

Systemic sclerosis (SSc) is an autoimmune disease characterized by overproduction of extracellular matrix (ECM) and multiorgan fibrosis. Animal studies pointed to bone marrow-derived cells as a potential source of pathological ECM-producing cells in immunofibrotic disorders. So far, involvement of monocytes and macrophages in the fibrogenesis of SSc remains poorly understood.

Methods and results

Immunohistochemistry analysis showed accumulation of CD14⁺ monocytes in the collagen-rich areas, as well as increased amount of alpha smooth muscle actin (αSMA)-positive fibroblasts, CD68⁺ and mannose-R⁺ macrophages in the heart and lungs of SSc patients. The full genome transcriptomics analyses of CD14⁺ blood monocytes revealed

SUBMITTER: Rudnik M 

PROVIDER: S-EPMC8421541 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature