Emerging Biomarkers and Therapeutic Strategies for Refractory Bullous Pemphigoid.

ABSTRACT: Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disorder in the elderly. Systemic and topical use of glucocorticoids and immunosuppressants has been shown to be effective in most patients. However, refractory BP patients are challenged to clinicians with severe clinical symptoms, resistance to treatment, and high relapse rate. How to predict and assess the refractory and severity of bullous pemphigoid is the key issue in clinical practice, and the urgent need for precision medicine in refractory patients is driving the search for biomarkers and biologics. Recently, some biomarkers, such as the level of specific autoantibodies and released cytokines, have been proposed as the potential parameters to reflect the disease severity and predict the treatment respons

SUBMITTER: Zhou T 

PROVIDER: S-EPMC8421646 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature