Optimized Dosing Regimens of Meropenem in Septic Children Receiving Extracorporeal Life Support.

ABSTRACT: Objectives: To develop a population pharmacokinetic model of meropenem in children with sepsis receiving extracorporeal life support (ECLS) and optimize the dosage regimen based on investigating the probability of target attainment (PTA). Methods: The children with sepsis were prospectively enrolled in a pediatric intensive care unit from January 2018 to December 2019. The concentration-time data were fitted using nonlinear mixed effect model approach by NONMEM program. The stochastic simulation considering various scenarios based on proposed population pharmacokinetics model were conducted, and the PTAs were calculated to optimize the dosage regimens. Results: A total of 25 children with sepsis were enrolled, of whom13 received ECMO, 9 received CRRT, and 4 received EC

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8421735 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature