Characterization of Emerging Pathogens Carrying bla_KPC-2 Gene in IncP-6 Plasmids Isolated From Urban Sewage in Argentina.

ABSTRACT: Untreated wastewater is a reservoir for multidrug-resistant bacteria, but its role in the spread of antibiotic resistance in the human population remains poorly investigated. In this study, we isolated a KPC-2-producing ST2787 Klebsiella quasipneumoniae subsp. quasipneumoniae (WW14A), recovered from raw sewage at a wastewater treatment plant in Argentina in 2018 and determined its complete genome sequence. Strain WW14A was resistant to all β-lactams, ciprofloxacin and amikacin. A core genome phylogenetic analysis indicated that WW14A was closely related to a GES-5-producing Taiwanese strain isolated from hospital wastewater in 2015 and it was clearly distinct from strains isolated recently in Argentina and Brazil. Interestingly, bla_KPC-2 was harbored by a re

SUBMITTER: Ghiglione B 

PROVIDER: S-EPMC8421773 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature