How Different Albumin-Binders Drive Probe Distribution of Fluorescent RGD Mimetics.

ABSTRACT: The biodistribution of medical imaging probes depends on the chemical nature of the probe and the preferred metabolization and excretion routes. Especially targeted probes, which have to reach a certain (sub)cellular destination, have to be guided to the tissue of interest. Therefore, small molecular probes need to exhibit a well-balanced polarity and lipophilicity to maintain an advantageous bioavailability. Labelled antibodies circulate for several days due to their size. To alter the biodistribution behavior of probes, different strategies have been pursued, including utilizing serum albumin as an inherent transport mechanism for small molecules. We describe here the modification of an existing fluorescent RGD mimetic probe targeted to integrin α_vβ₃ with three diff

SUBMITTER: Holtke C 

PROVIDER: S-EPMC8421774 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature