The Impact of Homocysteine on the Risk of Hormone-Related Cancers: A Mendelian Randomization Study.

ABSTRACT: Background: Aberrant homocysteine level is associated with metabolic disorders and DNA damage, which may be involved in the carcinogenesis of hormone-related cancers, but clinical results of observational studies are controversial. In this study, we investigated the causal relationships between plasma homocysteine and breast cancer (BRCA), prostate cancer (PrCa), and renal cell carcinoma (RCC) using Mendelian randomization (MR) analyses. Design and Methods: To investigate the putative causal associations between homocysteine and the aforementioned three types of cancers, a two-sample MR study was employed for the study. The primary strategy for summary data analyses was the inverse-variance-weighted (IVW) approach. In our study, the single-nucleotide polymorphisms (SNPs) excl

SUBMITTER: He Q 

PROVIDER: S-EPMC8421785 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature