Impact of COVID-19 on Liver Transplantation in Hong Kong and Singapore: A Modelling Study.

ABSTRACT:

Background

Liver transplantation (LT) activities during the COVID-19 pandemic have been curtailed in many countries. The impact of various policies restricting LT on outcomes of potential LT candidates is unclear.

Methods

We studied all patients on the nationwide LT waitlists in Hong Kong and Singapore between January 2016 and May 2020. We used continuous time Markov chains to model the effects of different scenarios and varying durations of disruption on LT candidates.

Findings

With complete cessation of LT, the projected 1-year overall survival (OS) decreased by 3•6%, 10•51% and 19•21% for a 1-, 3- and 6-month disruption respectively versus no limitation to LT, while 2-year OS decreased by 4•1%, 12•55%, and 23•43% respectively. When only urgent (acute-on-chronic liv

SUBMITTER: Tan EX 

PROVIDER: S-EPMC8421812 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature