Increased phosphorylated CREB1 protein correlates with poor prognosis in clear cell renal cell carcinoma.

ABSTRACT:

Background

This study aims to investigate the level of cAMP response element-binding protein 1 (phospho S133) (p-CREB1) protein in clear cell renal cell carcinoma (ccRCC) and evaluates its prognosis significance.

Methods

Immunohistochemistry (IHC) method was performed to detect p-CREB1 staining in 233 ccRCC patients. Three or more high-power fields per tissue section were equally captured by a Leica DMRXA microphotographic system, and average staining intensity (optical density, OD) was analyzed by Leica Qwin Standard V2.6 system. Univariate and multivariate Cox proportional regression model was performed to assess the correlation of p-CREB1 staining and clinical outcomes.

Results

IHC proved that the level of p-CREB1 protein was significantly higher in tumor tissues t

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8421817 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature