Identification of autophagy-related long non-coding RNA prognostic and immune signature for clear cell renal cell carcinoma.

ABSTRACT:

Background

Studies over the past decade have shown that long non-coding RNAs (lncRNAs) play an essential role in the tumorigenesis and progression of kidney renal clear cell carcinoma (KIRC). Meanwhile, autophagy has been demonstrated to regulate KIRC pathogenesis and targeting therapy resistance. However, the prognostic value of autophagy-related lncRNAs in KIRC patients has not been reported before.

Methods

In this study, we obtained transcriptome data of 611 KIRC cases from the TCGA database and 258 autophagy-related mRNAs from the HADb database to identify autophagy-related lncRNAs by co-expression network. A prognostic model was then established basing on these autophagy-related lncRNAs, dividing patients into high-risk and low-risk groups. Survival analysis, clinical v

SUBMITTER: Cui Y 

PROVIDER: S-EPMC8421821 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature