Discovery of bladder cancer biomarkers in paired pre- and postoperative urine samples.

ABSTRACT:

Background

Bladder cancer (BC), a common cancer of the urinary system, has a low mortality but an extremely high recurrence rate. Patients who have undergone initial surgical treatment often undergo frequent prognostic examinations with a substantial burden of discomfort and costs. Urine samples can reflect early disease processes in the urinary system and may be an excellent source of biomarkers.

Methods

In the present study, we used the liquid chromatography with tandem mass spectrometry (LC-MS/MS) to perform proteomic analysis of pre- and postoperative urine samples from patients with stage III BC to identify biomarkers of cancer prognosis. Candidate biomarkers from proteomic analysis were simultaneously validated using western blotting in an independent cohort and immuno

SUBMITTER: Li X 

PROVIDER: S-EPMC8421825 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature