Genetically determined low income modifies Alzheimer's disease risk.

ABSTRACT:

Background

Socioeconomic status (SES) is considered to be associated with the prevalence of Alzheimer's disease (AD). However, the causal association remain unclear. Here, we determining whether income has a causal protective effect on the risk of developing AD using Mendelian randomization (MR).

Methods

Single-nucleotide polymorphisms (SNPs) that are strongly associated with household income levels (P<5×10^-8) from the UK Biobank (UKB) (n=286,301) were selected as instrumental variables for this study. Confounding instruments were removed through data set browsing. Selected SNPs were then harmonized with results from an AD genome-wide meta-analysis (71,880 cases, 383,378 controls) including both case-control and proxy cases. The analysis was conducted using MR met

SUBMITTER: Wang RZ 

PROVIDER: S-EPMC8421944 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature