The effects of smoking and drinking on the oral and esophageal microbiota of healthy people.

ABSTRACT:

Background

To explore the effects of smoking and drinking on the microbiota in the saliva and three segments of the esophagus (upper, middle, and lower) in healthy individuals.

Methods

Paired saliva and brush specimens were obtained from 76 participants who underwent upper gastrointestinal (UGI) endoscopic examination for UGI cancer screening. The esophageal microbiota was investigated by 16S rRNA gene profiling via next-generation sequencing.

Results

The saliva samples from non-smoking and non-drinking participants had a greater abundance of Neisseria, Prevotella, Porphyromonas, and Rothia, and lower levels of Streptococcus, Actinobacillus, and Haemophilus compared to the esophagus. There were no significant differences in th

SUBMITTER: Li Z 

PROVIDER: S-EPMC8421972 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature