Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice.

ABSTRACT: The increasing worldwide prevalence of obesity, fatty liver diseases and the emerging understanding of the important roles lipids play in various other diseases is generating significant interest in lipid research. Lipid visualization in particular can play a critical role in understanding functional relations in lipid metabolism. We investigated the potential of multispectral optoacoustic tomography (MSOT) as a novel modality to non-invasively visualize lipids in laboratory mice around the 930nm spectral range. Using an obesity-induced non-alcoholic fatty liver disease (NAFLD) mouse model, we examined whether MSOT could detect and differentiate different grades of hepatic steatosis and monitor the accumulation of lipids in the liver quantitatively over time, without the use of contrast ag

SUBMITTER: Huang S 

PROVIDER: S-EPMC8422073 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature