Effects of ligustrazine on the expression of neurotransmitters in the trigeminal ganglion of a rat migraine model.

ABSTRACT:

Background

Migraine is one of the most common neurological diseases which has been treated by active substances from traditional Chinese medicine (TCM), such as ligustrazine, an extract of the Chinese herb Chuanxiong. However, the pathogenesis of migraine and the curative mechanisms of ligustrazine have remained unclear. The genes P2X3, TRPV1, ERK, and c-fos have been implicated to play a role. In this work, we attempted to elucidate the analgesic mechanism of ligustrazine using a classic migraine-representative rat model.

Methods

The migraine rat model was established by administration of nitroglycerin (NTG). Ligustrazine treatment was administered by intravenous injection. The animal's behavior was continuously recorded, and then trigeminal gang

SUBMITTER: Li H 

PROVIDER: S-EPMC8422085 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature