Genomic instability-associated lncRNA signature predicts prognosis and distinct immune landscape in gastric cancer.

ABSTRACT:

Background

Characterized by multiple features, genomic stability-related markers, such as microsatellite instability (MSI), were regulated as an important predictor of chemotherapy and immunity responses in cancer treatment. The aim of our study was to identify a genomic instability-associated long non-coding RNA (lncRNA) signature to help predict the survival and therapy response of gastric cancers (GCs).

Methods

We used RNA sequencing and single nucleotide variant (SNV) data from The Cancer Genome Atlas-stomach adenocarcinoma (TCGA-STAD) datasets to explore genomic instability-associated lncRNAs. Hierarchical cluster analyses of 197 differentially expressed genomic instability-associated lncRNAs were performed to separate GC patients into two groups, namely, the genomicall

SUBMITTER: Sun J 

PROVIDER: S-EPMC8422092 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature