A pilot study of near-infrared fluorescence guided surgery for primary tumor localization and lymph node mapping in colorectal cancer.

ABSTRACT:

Background

This pilot study aimed to evaluate the feasibility of near-infrared fluorescence imaging for primary tumor localization, lymph node mapping, and metastatic lymph node detection in colorectal cancer (CRC) using indocyanine green (ICG).

Methods

A total of 11 patients with CRC were prospectively enrolled. ICG (25 mg dissolved in 30 mL sterile water) was intravenously injected preoperatively, and the fluorescence intensity of the primary tumor, lymph nodes, and normal tissues, as well as the signal-to-background ratio (SBR) and contrast-to-noise ratio (CNR) were measured at 0.5, 1, 2, 4, and 24 h after ICG injection.

Results

The primary tumor could be located intraoperatively, and the tumor boundary was clear at 2-4 h. There was good contrast in the fluorescenc

SUBMITTER: Cao Y 

PROVIDER: S-EPMC8422097 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature