Protective effect of ischemic postconditioning on ischemia reperfusion injury in steatotic rat livers.

ABSTRACT:

Background

Hepatic steatosis creates a significant risk of liver resection and transplantation and is extremely susceptible to ischemia/reperfusion (I/R) injury. Ischemic postconditioning (IPostC) has been shown to attenuate I/R injury in normal livers; however, its role in steatotic livers remains unknown. The current study sought to explore whether IPostC could attenuate normothermic I/R injury in rats with steatotic livers and to investigate potential protective measures.

Methods

Hepatic steatosis was triggered in Wistar rats fed high-fat diets. The role of IPostC was detected in normal and steatotic livers with 30 min of ischemia and 6 h of reperfusion. Blood and liver tissues were collected to assess hepatocyte damage, lipid peroxidation, inflammatory factors, neutrophi

SUBMITTER: He JX 

PROVIDER: S-EPMC8422122 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature