Effectiveness and safety of bevacizumab in extensive-disease small cell lung cancer: a systemic review and meta-analysis.

ABSTRACT:

Background

Small cell lung cancer (SCLC) is highly invasive and poorly prognostic. The effects of chemotherapy with bevacizumab are promising on other tumors but unclear in extensive-disease SCLC (ED-SCLC). A systemic review and meta-analysis were performed to investigate the efficacy and toxicity in ED-SCLC patients.

Methods

A review of current studies was performed on electronic databases and other sources to identify publications of ED-SCLC patients who received bevacizumab. Endpoints included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and complications.

Results

Nine relevant articles with six single-arm and three two-arm studies were identified. Four hundred seventy-six patients were included,

SUBMITTER: He J 

PROVIDER: S-EPMC8422128 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature