The methylation modification of m6A regulators contributes to the prognosis of head and neck squamous cell carcinoma.

ABSTRACT:

Background

N6-methyladenosine (m6A) regulation is a common type of messenger ribonucleic acid (mRNA) modification, and has been proven to contribute to the malignant behavior of tumors. However, the expression pattern and the prognostic role of m6A RNA methylation regulators in head and neck squamous cell carcinoma (HNSCC) remains unclear.

Methods

We downloaded the data of 422 patients from The Cancer Genome Atlas (TCGA) database. The relationship between the expression level of m6A RNA methylation regulators and clinicopathological variables in HNSCC was analyzed by R language.

Results

The m6A gene alteration was significantly correlated with tumor grade and tumor stage. Next, a least absolute shrinkage and selection operator (LASSO) Cox regression model was used to

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8422133 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature