Risk factors for radiation induced lymphopenia in patients with breast cancer receiving adjuvant radiotherapy.

ABSTRACT:

Background

This study aimed to investigate radiation-induced lymphopenia and its potential risk factors in patients with breast cancer receiving adjuvant radiotherapy.

Methods

Breast cancer patients received adjuvant radiotherapy (RT) at our hospital with peripheral lymphocyte counts (PLC) at pre-and immediately after RT (post-RT) were eligible. The primary endpoints were any grade of lymphopenia post-RT and nadir-PLC/pre-PLC <0.8. Patient characteristics, tumor factors, and treatment factors were collected for risk assessment. Data are presented as mean and 95% confidence interval (CI) unless otherwise specified. Matched analysis was used to compare the statistical significance between different RT techniques.

Results

A total of 735 consecutive patients met the study

SUBMITTER: Chen F 

PROVIDER: S-EPMC8422134 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature