TPM3 mediates epithelial-mesenchymal transition in esophageal cancer via MMP2/MMP9.

ABSTRACT:

Background

Esophageal cancer (EC) is a malignant tumor with high mortality. Correlations have been found between the expression level of tropomyosin 3 (TPM3) and the depth of tumor invasion, lymph node metastasis, and the 5-year survival rate. However, the specific mechanisms underlying EC remain unclear.

Methods

Stably transfected TPM3-overexpresing and TPM3-knockdown esophageal squamous cell carcinoma (ESCC) cell lines (ECa109 and EC9706) were constructed, and the association between TPM3 and the proliferation, invasion, and migration of ESCC was investigated using molecular biology methods. The associations between TPM3 and matrix metalloproteinase (MMP)2/9 or epithelial-mesenchymal transition (EMT)-related proteins were verified, and the potential tumor-promoting mechani

SUBMITTER: Chen S 

PROVIDER: S-EPMC8422148 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature